Nicotinamide Adenine Dinucleotide
NAD+ | NAD | Coenzyme I
Mechanism of Action
NAD+ is a fundamental coenzyme in cellular energy metabolism, serving as the primary electron carrier in mitochondrial oxidative phosphorylation and as an essential substrate for sirtuins (SIRT1-7), PARPs, and CD38/CD157 enzymes. NAD+ levels decline significantly with age, impairing sirtuin-mediated gene regulation, mitochondrial function, and DNA repair capacity.
The 500mg product contains the same NAD+ compound as the 1000mg biofermented version at a lower quantity. See the NAD 1000mg entry for comprehensive research details on NAD+ biology, the role of NAD+ decline in aging, and the therapeutic potential of NAD+ restoration.
Key Research Findings
- Yoshino et al. (2011) showed NAD+ restoration normalizes glucose tolerance and mitochondrial function in aged mice.
- Gomes et al. (2013) demonstrated declining NAD+ causes pseudohypoxia through disrupted SIRT1-HIF1alpha signaling.
- Verdin (2015) reviewed NAD+ as a central regulator of aging, metabolism, and neurodegeneration.
- Rajman et al. (2018) comprehensively reviewed the in vivo evidence for therapeutic NAD+ boosting.
References
Dosage in Research
IV NAD+ protocols in clinical settings use 250-750 mg infusions. The 500mg vial provides a standard research quantity.
Storage & Handling
Store lyophilized powder at -20C, protected from light and moisture. NAD+ is hygroscopic. Reconstituted solutions should be used promptly.
Frequently Asked Questions
What is the difference between NAD 500mg and NAD 1000mg Biofermented?
Both contain the same NAD+ coenzyme. The 1000mg biofermented version provides double the quantity and is produced through microbial fermentation for high purity. Choose based on your protocol's quantity requirements.
Source Nicotinamide Adenine Dinucleotide for your research
98%+ purity, third-party tested, COA included